5 mcg/mL according to institution practice
What is L
A
Phenytoin is 90% bound, but only the free fraction circulates through plasma membranes and is biologically active
The mean free phenytoin fraction was 0
Differences in formulation between brand names and
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levels that are at target (10-20) may actually be greater than 20 with hypoalbuminemia Levels may be hard to interpret for patients on HD or on valproic acid
It is also a Vaughan-Williams class IB antiarrhythmic agent, although it is now infrequently used for that indication
Dilantin-30
Toxicity is a constant possibility because of the manner in which phenytoin is metabolized
The reference range of free phenytoin is 1-2
The intravenous form, fosphenytoin, is used for status epilepticus that does not improve with benzodiazepines
Because there is approximately an 8% increase in drug content with the free acid form over that of the sodium salt, dosage adjustments and serum level monitoring may be necessary when switching from a product formulated with the free acid to a
Phenytoin levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity
The following equation is a simple pharmacokinetic equation to estimate a loading dose or resulting serum concentration of a drug
Have the level of phenytoin in your blood checked as you have been told by your doctor
Call your doctor right away if you have any However, total phenytoin levels can be misleading in patients with factors such as low plasma albumin that alter the free (unbound) concentrations of phenytoin
2) DILANTIN is available as 30 mg and 100 mg extended phenytoin sodium capsules
Because there is approximately an 8% increase in drug content with the free acid form over that of the sodium salt, dosage adjustments and